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p = percentage calculated from a sample n = sample size.

If the confidence interval, according to the formula, is too wide, you can cut it down by using a larger sample. From the formula you can infer that if you multiply the sample size by four, the confidence interval will shrink into half. Note that the formula is independent of the size of the population.

The formulas for calculating statistical significances are exact but somewhat cumbersome to use because you have to use a different formula for almost every type of statistic. That is why these formulas are not presented here. A very rough rule of thumb says that for doing analysis of variance you will need 30 cases, for regression analysis 40 cases multiplied by the number of variables, and for a Chi test at least five cases in each cell in the table of distribution. In important projects with ample resources, a statistician is usually consulted for calculating the size of a sample. In a research project with limited resources, the rule of thumb is: Use as large a sample as you can afford.

There is no formula to determine the size of a non-random sample. Often, especially in qualitative research, you may simply enlarge your sample gradually and analyse the results as they come. When new cases no longer yield new information, you may conclude that your sample is saturated, and finish the job. This method is however very sensitive to biased sampling, so you should be careful and make sure that you do not omit any groups from your population.

Remember also that if a sample is biased it does not help to increase the sample size. The added sample will be just as biased if you use the same method of selection as for the original sample.

If you can afford to make a second sample, try creating it with another method of selection. Keep initially separate the data from each of the samples. By comparing them you have an excellent means of judging the presence of bias in either of them.

Before deciding the size of a non-random sample, you might want to read how to assess the results from a non-random sample. Otherwise you might experience quite a nasty surprise when trying, too late, to define the field where your results could be declared valid.

It often happens that some cases in the sample turn out fruitless because they cannot be reached, measurements fail, interviewees refuse to co-operate etc. The most usual method is to overdimension the sample slightly, and then simply forget the failing cases.

If you, however, want do the sampling very carefully, you should ask yourself: Is it probable or possible that the failing cases differ from the successful ones in any respect that is interesting in your project? Only when the answer is no , the absence of these cases will not introduce bias in the results. If you, on the contrary, think that the failing cases systematically differ from the rest, you can try to neutralize the bias by giving different weights to the data that come in time and those that come first after a reminder. The method is explained in The Problem of No-Reply.

ISSN: 2048-9145

Pharmaceutical Bioprocessing

Welcome to the Pharmaceutical Bioprocessing

ISI-ESCI Indexed

Pharmaceutical Bioprocessing as a field of study has gained great significance at with advancements in the field of biomedical research paving the way for innovative pharmaceutical products. Pharmaceutical Bioprocessing Journal thus discusses the latest happenings in the drug design, production and delivery in order to offer efficient solutions to mitigate the public health concerns.

This scholarly journal offers an Open Access platform to the scholars, amateurs, clinical practitioners and students that are keen in contributing their findings in this field. The journal includes wide areas of studies in this field by including topics like Process design, development, scale-up and automation; Production facilities, equipment and the use of disposables; Cell expression systems for biopharmaceutical production; Bioreactors, Upstream and downstream processing; Bio-containment, safety and cGMP processes; Production of recombinant proteins, mAbs, vaccines and cell therapies; Analysis: processing design, process analytics and release criteria; Bioformulation, validation, regulation and patient delivery; Regulatory issues and other areas of debate; Disposable Bioprocessing Systems.

Not limited to the categories mentioned above the journal offers thoroughly reviewed original research as research articles, review articles, case studies, commentaries, Short Communication, and Letters to the Editors in this field.

Indexing Information : Pharmaceutical Bioprocessing Journal is indexed in the quality indexing sites such as ISI-ESCI , Chemical Abstracts for increasing visibility and discoverability.

Indexing Information ISI-ESCI
*2017 Journal Impact Factor was established by dividing the number of articles published in 2015 and 2016 with the number of times they are cited in 2017 based on Google Scholar Citation Index database. If 'X' is the total number of articles published in 2015 and 2016, and 'Y' is the number of times these articles were cited in indexed journals during 2017 then, journal impact factor = Y/X

Current Issue

Volume 6, Issue 3 ( 2018)

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Recently Published Articles

Research Article p. 89-92

Author(s): Yuhui Wang, Yue She Wuyin Li


Objective: To compare the effect of intravenous and intra-articular injection of tranexamic acid on blood loss in total knee arthroplasty (TKA). Methods: A total of 90 patients treated with..

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